Donna H. Korzick
Associate Professor of Physiology and Kinesiology, Chair Intercollege Program in Physiology
106 Noll Laboratory
The Pennsylvania State University
University Park PA 16802
Ph.D., 1994, Physiology, Penn State
Post-menopausal women, aging and cardiovascular disease risk; animal models of estrogen deficiency, ischemia-reperfusion injury and cardioprotection with a particular emphasis on estrogen receptors, PKC-dependent signaling and exercise.
Aging, post-menopausal women, cardiovascular disease risk, and mitochondrial dynamics
Animal models include rodent aging, estrogen deficiency, ischemia-reperfusion injury, chronic ethanol ingestion, and exercise
Estrogen receptor and PKC-dependent protective signaling in relation to oxidant stress
Hunter JC, Kostyak JC, Novotny JL, Simpson AM, and Korzick DH. Estrogen deficiency decreases ischemic tolerance reduces in aged rat myocardium: roles of PKCδ, PKCε, Akt, and GSK3β. Am J Physiol. 292: R800-R809, 2007.
Korzick DH, JC Kostyak, JC Hunter and KW Saupe. Local Delivery of PKCε-Activating Peptide Mimics Ischemic Preconditioning in Aged Hearts Through GSK3β but not F1ATPase Inactivation. Am J Physiol. 293: H2056-H2063, 2007.
Novotny JL, Simpson AM, Tomicek NA, Lancaster TL and Korzick DH. Rapid Estrogen Receptor-α Activation Improves Ischemic Tolerance in Aged Female Rats Through a Novel PKCe-Dependent Mechanism. Endocrinology (revision in review).
- Domains of Health and Behavior
- Populations of Special Interest