Donna H. Korzick
Professor of Physiology and Kinesiology, Chair Intercollege Program in Physiology
106 Noll Laboratory
The Pennsylvania State University
University Park PA 16802
Ph.D., 1994, Physiology, Penn State
Post-menopausal women, aging and cardiovascular disease risk; animal models of estrogen deficiency, ischemia-reperfusion injury and cardioprotection with a particular emphasis on estrogen receptors, PKC-dependent signaling and exercise.
Aging, post-menopausal women, cardiovascular disease risk, and mitochondrial dynamics
Animal models include rodent aging, estrogen deficiency, ischemia-reperfusion injury, chronic ethanol ingestion, and exercise
Estrogen receptor and PKC-dependent protective signaling in relation to oxidant stress
Hunter JC, Kostyak JC, Novotny JL, Simpson AM, and Korzick DH. Estrogen deficiency decreases ischemic tolerance reduces in aged rat myocardium: roles of PKCδ, PKCε, Akt, and GSK3β. Am J Physiol. 292: R800-R809, 2007.
Korzick DH, JC Kostyak, JC Hunter and KW Saupe. Local Delivery of PKCε-Activating Peptide Mimics Ischemic Preconditioning in Aged Hearts Through GSK3β but not F1ATPase Inactivation. Am J Physiol. 293: H2056-H2063, 2007.
Novotny JL, Simpson AM, Tomicek NA, Lancaster TL and Korzick DH. Rapid Estrogen Receptor-α Activation Improves Ischemic Tolerance in Aged Female Rats Through a Novel PKCe-Dependent Mechanism. Endocrinology (revision in review).
- Domains of Health and Behavior
- Populations of Special Interest